YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis

YTHDF1 phase separation triggers the fate transition of spermatogonial stem cells by activating the IκB-NF-κB-CCND1 axis

Summary: N6-methyladenosine (m6A) modification controls cell fate determination. Here, we show that liquid-liquid phase separation (LLPS) of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1), a pivotal m6A “reader” protein, promotes the transdifferentiation of spermatogonial stem cells (SSCs) in...

Full description

Bibliographic Details
Main Authors: Qian Fang, Geng G. Tian, Qian Wang, Mengyao Liu, Lin He, Shengtian Li, Ji Wu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Cell Reports
Subjects:
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472300414X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472300414X

Similar Items