Determination of the microscopic acid dissociation constant of piperacillin and identification of dissociated molecular forms
For amphoteric ß-lactam antibiotics, the acid dissociation constant (pKa) is a fundamental parameter to characterize physicochemical and biochemical properties of antibiotics and to predict persistence and removal of drugs. pKa of piperacillin (PIP) is determined by potentiometric titration with a g...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1177128/full |