Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice

Pathogenic mutations in the leucine-rich repeat kinase 2 (<i>LRRK2</i>) gene are frequent causes of familial Parkinson’s Disease (PD), an increasingly prevalent neurodegenerative disease that affects basal ganglia circuitry. The cellular effects of the G2019S mutation in the <i>LRR...

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Bibliographic Details
Main Authors: Giacomo Sitzia, Olga Skiteva, Karima Chergui
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/12/11/1635