AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA

AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA

The Aryl Hydrocarbon Receptor (AhR) is a transcription factor that, when activated by ligand-binding, has been shown to regulate the immune response. Pertussis Toxin (PTX) is a virulence factor found in Bordetella pertussis, a human respiratory pathogen that causes whooping cough. PTX promotes colon...

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Bibliographic Details
Main Authors: Zinah Zamil Al-Ghezi, Narendra Singh, Pegah Mehrpouya-Bahrami, Philip Brandon Busbee, Mitzi Nagarkatti, Prakash S. Nagarkatti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Microbiology
Subjects:
aryl hydrocarbon receptor (AhR)
pertussis toxin
2
3
7
8-Tetrachlorodibenzo-p-dioxin
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02349/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02349/full

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