Anti-Tumor Activity of Orally Administered Gefitinib-Loaded Nanosized Cubosomes against Colon Cancer

Anti-Tumor Activity of Orally Administered Gefitinib-Loaded Nanosized Cubosomes against Colon Cancer

Gefitinib (GFT) is a tyrosine kinase inhibitor drug used as a first-line treatment for patients with advanced or metastatic non-small cell lung, colon, and breast cancer. GFT exhibits low solubility and hence low oral bioavailability, which restricts its clinical application. One of the most importa...

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Bibliographic Details
Main Authors: Ahmed A. El-Shenawy, Mahmoud M. A. Elsayed, Gamal M. K. Atwa, Mohammed A. S. Abourehab, Mohamed S. Mohamed, Mohammed M. Ghoneim, Reda A. Mahmoud, Shereen A. Sabry, Walid Anwar, Mohamed El-Sherbiny, Yasser A. Hassan, Amany Belal, Abd El hakim Ramadan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
gefitinib
nanosized cubosomes
nanoparticles
colon cancer
gene expression
histopathological examination
Online Access:https://www.mdpi.com/1999-4923/15/2/680

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https://www.mdpi.com/1999-4923/15/2/680

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