Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors

Phosphorylation of Spastin Promotes the Surface Delivery and Synaptic Function of AMPA Receptors

Synaptic plasticity is essential for cognitive functions such as learning and memory. One of the mechanisms involved in synaptic plasticity is the dynamic delivery of AMPA receptors (AMPARs) in and out of synapses. Mutations of SPAST, which encodes SPASTIN, a microtubule-severing protein, are consid...

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Bibliographic Details
Main Authors: Li Chen, Hanjie Wang, Shuhan Cha, Jiong Li, Jiaqi Zhang, Jiaming Wu, Guoqing Guo, Jifeng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
spastin
phosphorylation
AMPA receptor
synaptic plasticity
microtubule
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.809934/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.809934/full

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