Alpha-tocopherol enhances spermatogonial stem cell proliferation and restores mouse spermatogenesis by up-regulating BMI1

Alpha-tocopherol enhances spermatogonial stem cell proliferation and restores mouse spermatogenesis by up-regulating BMI1

PurposeSpermatogonial stem cells (SSCs) are essential for maintaining reproductive function in males. B-lymphoma Mo-MLV insertion region 1 (BMI1) is a vital transcription repressor that regulates cell proliferation and differentiation. However, little is known about the role of BMI1 in mediating the...

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Bibliographic Details
Main Authors: Mei Peng, Jintao Wu, Weifan Wang, Tianlong Liao, Simeng Xu, Di Xiao, Zuping He, Xiaoping Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Nutrition
Subjects:
BMI1
spermatogonial stem cells
proliferation and DNA synthesis
DNA damage
sperm count and malformation
α-tocopherol
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2023.1141964/full

Internet

https://www.frontiersin.org/articles/10.3389/fnut.2023.1141964/full

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