Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

ObjectiveThe monocyte–macrophage system is central to the host’s innate immune defense and in resolving injury. It is reported to be dysfunctional in acute-on-chronic liver failure (ACLF). The disease-associated alterations in ACLF monocytes are not fully understood. We investigated the mechanism of...

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Main Authors: Deepanshu Maheshwari, Dhananjay Kumar, Rakesh Kumar Jagdish, Nidhi Nautiyal, Ashinikumar Hidam, Rekha Kumari, Rashi Sehgal, Nirupama Trehanpati, Sukriti Baweja, Guresh Kumar, Swati Sinha, Meenu Bajpai, Viniyendra Pamecha, Chhagan Bihari, Rakhi Maiwall, Shiv Kumar Sarin, Anupam Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
bioenergetics
ucMSC therapy
regeneration
acute-on-chronic liver failure (ACLF)
monocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.856587/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.856587/full

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