Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

Bioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure

ObjectiveThe monocyte–macrophage system is central to the host’s innate immune defense and in resolving injury. It is reported to be dysfunctional in acute-on-chronic liver failure (ACLF). The disease-associated alterations in ACLF monocytes are not fully understood. We investigated the mechanism of...

Full description

Bibliographic Details
Main Authors:	Deepanshu Maheshwari, Dhananjay Kumar, Rakesh Kumar Jagdish, Nidhi Nautiyal, Ashinikumar Hidam, Rekha Kumari, Rashi Sehgal, Nirupama Trehanpati, Sukriti Baweja, Guresh Kumar, Swati Sinha, Meenu Bajpai, Viniyendra Pamecha, Chhagan Bihari, Rakhi Maiwall, Shiv Kumar Sarin, Anupam Kumar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	bioenergetics ucMSC therapy regeneration acute-on-chronic liver failure (ACLF) monocyte
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.856587/full

Similar Items

Soluble factors and suppressive monocytes can predict early development of sepsis in acute‐on‐chronic liver failure
by: Pushpa Yadav, et al.
Published: (2022-08-01)

Granulocyte-Macrophage Colony-Stimulating Factor Modulates Myeloid-Derived Suppressor Cells and Treg Activity in Decompensated Cirrhotic Patients With Sepsis
by: Rashi Sehgal, et al.
Published: (2022-06-01)

Comparing Three Profoundly Influential Prognostic Scores in Cirrhotic Patients with Acute-on-Chronic-Liver Failure Admitted to the ICU: Prediction of One-Month Mortality—A Retrospective Cohort Study
by: Shih-Hua Lin, et al.
Published: (2023-10-01)

Sarcoidosis Presenting as Acute on Chronic Liver FailureReport of the First Case
by: Cyriac Abby Philips, et al.
Published: (2016-06-01)

Nonselective beta‐blockers reduce mortality in patients with acute‐on‐chronic liver failure
by: Anand V. Kulkarni, et al.
Published: (2022-06-01)

HMGB1-Induced Hepatocyte Pyroptosis Expanding Inflammatory Responses Contributes to the Pathogenesis of Acute-on-Chronic Liver Failure (ACLF)
by: Hou W, et al.
Published: (2021-12-01)

Clinical profile and outcome among patients with acute-on-chronic liver failure admitted in the intensive care unit
by: Marwa Lotfi El Sayed, et al.
Published: (2021-09-01)

Construction of a novel prognostic scoring model for HBV-ACLF liver failure based on dynamic data
by: Qun Cai, et al.
Published: (2024-07-01)

Clinical outcomes and predictors in patients with acute on chronic liver failure in Southern Taiwan
by: Pao-Yuan Huang, et al.
Published: (2025-03-01)

miRNA signatures can predict acute liver failure in hepatitis E infected pregnant females
by: Nirupma Trehanpati, et al.
Published: (2017-04-01)

Role of tenofovir and telbivudine in treatment of hepatitis B related acute on chronic liver failure
by: Debraj Malakar, et al.
Published: (2021-01-01)

Prognostic Value of Platelet-to-Monocyte Ratio for Mortality in HBV-Related Acute-on-Chronic Liver Failure
by: Qi X, et al.
Published: (2024-07-01)

Copy number gain of pro-inflammatory genes in patients with HBV-related acute-on-chronic liver failure
by: Fengming Sun, et al.
Published: (2020-12-01)

Bikunin: A Promising Prognostic Biomarker for Acute-on-Chronic Liver Failure in Patients with Viral Hepatitis B
by: Qin G, et al.
Published: (2023-08-01)

The Aachen ACLF ICU score predicts ICU mortality in critically ill patients with acute-on-chronic liver failure
by: Maike R. Pollmanns, et al.
Published: (2024-12-01)

Identification and validation of neutrophil-related biomarkers in acute-on-chronic liver failure
by: Wei Lin, et al.
Published: (2025-02-01)

The efficacy and safety of nucleos(t)ide analogues in the treatment of HBV-related acute-on-chronic liver failure: a meta-analysis
by: Yu Shi, et al.
Published: (2013-05-01)

Consensus document on acute-on-chronic liver failure (ACLF) established by the Mexican Association of Hepatology
by: Aldo Torre, et al.
Published: (2023-11-01)

Evaluation of treatment outcome in patients with acute-on-chronic liver failure using clinical scores
by: Milovanović Tamara, et al.
Published: (2020-01-01)

Observational study on the response of tenofovir monotherapy versus tenofovir plus telbivudine dual therapy in patients with hepatitis B virus related acute on chronic liver failure
by: Abul H Manik, et al.
Published: (2021-01-01)

Myostatin is associated with the presence and development of acute-on-chronic liver failure
by: Astrid Ruiz-Margáin, et al.
Published: (2023-08-01)

Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit
by: Osvely Méndez-Guerrero, et al.
Published: (2021-05-01)

Plasma thrombomodulin as a candidate biomarker for the diagnosis and prognosis of HBV-related acute-on-chronic liver failure
by: Zhou X, et al.
Published: (2024-03-01)

Galectin-9 as a new biomarker of acute-on-chronic liver failure
by: Jun Ling, et al.
Published: (2024-09-01)

Quantitative plasma proteomics identifies metallothioneins as a marker of acute-on-chronic liver failure associated acute kidney injury
by: Pragyan Acharya, et al.
Published: (2023-01-01)

The progress to establish optimal animal models for the study of acute-on-chronic liver failure
by: Hengben Zhai, et al.
Published: (2023-02-01)

Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure
by: Cornelius Engelmann, et al.
Published: (2018-10-01)

Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure
by: Yunyun Wang, et al.
Published: (2021-11-01)

Establishment of a new acute-on-chronic liver failure model
by: Fangfang Li, et al.
Published: (2017-05-01)

hUCMSCs Regulate Bile Acid Metabolism to Prevent Heart Failure–Induced Intestinal Injury by Inhibiting the Activation of the STAT3/NF‐κB/MAPK Signaling Pathway via TGR5
by: Zetian Wang, et al.
Published: (2025-01-01)

ShK‐modified UCMSCs Inhibit M1‐Like Macrophage Polarization and Alleviate Osteoarthritis Progression via PI3K/Akt Axis
by: Wenshu Wu, et al.
Published: (2025-03-01)

Serum CXCL1 Is a Prognostic Factor for Patients With Hepatitis B Virus–Related Acute-On-Chronic Liver Failure
by: Lanlan Xiao, et al.
Published: (2021-07-01)

Altered PGE2-EP2 is associated with an excessive immune response in HBV-related acute-on-chronic liver failure
by: Yunyun Wang, et al.
Published: (2019-03-01)

Human liver tissue transcriptomics revealed immunometabolic disturbances and related biomarkers in hepatitis B virus-related acute-on-chronic liver failure
by: Luo Yang, et al.
Published: (2022-12-01)

Models to predict the short-term survival of acute-on-chronic liver failure patients following liver transplantation
by: Min Yang, et al.
Published: (2022-02-01)

The Intrahepatic Expression and Distribution of BTLA and its Ligand HVEM in patients with HBV-related acute-on-chronic liver failure
by: Xu Huan, et al.
Published: (2012-10-01)

The Immune Pathogenesis of Acute-On-Chronic Liver Failure and the Danger Hypothesis
by: Rui Qiang, et al.
Published: (2022-07-01)

A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver
by: Lei Feng, et al.
Published: (2023-09-01)

CD200R Combined Neutrophil-Lymphocyte Ratio Predict 90-Day Mortality in HBV-Related Acute-On-Chronic Liver Failure
by: Yuxin Li, et al.
Published: (2021-12-01)

Early prediction of acute-on-chronic liver failure development in patients with diverse chronic liver diseases
by: Yuqiang Shen, et al.
Published: (2024-11-01)