CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation.

CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation.

Over the last decade, multiple broadly neutralizing monoclonal antibodies (bN-mAbs) to the HIV-1 envelope protein (Env) gp120 have been described. Many of these recognize epitopes consisting of both amino acid and glycan residues. Moreover, the glycans required for binding of these bN-mAbs are early...

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Bibliographic Details
Main Authors: Gabriel Byrne, Sara M O'Rourke, David L Alexander, Bin Yu, Rachel C Doran, Meredith Wright, Qiushi Chen, Parastoo Azadi, Phillip W Berman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6133382?pdf=render

Internet

http://europepmc.org/articles/PMC6133382?pdf=render

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