Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex

ABSTRACT Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control the size and architecture of the brain and understanding the mechanisms reg...

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Bibliographic Details
Main Authors: Beth Mann, Jeremy Chase Crawford, Kavya Reddy, Josi Lott, Yong Ha Youn, Geli Gao, Cliff Guy, Ching-Heng Chou, Daniel Darnell, Sanchit Trivedi, Perrine Bomme, Allister J. Loughran, Paul G. Thomas, Young-Goo Han, Elaine I. Tuomanen
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
cell wall
hedgehog signaling
neocortex
Toll-like receptors
Online Access:https://journals.asm.org/doi/10.1128/mbio.00510-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00510-23

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