Enhancing and inhibitory motifs regulate CD4 activity

Enhancing and inhibitory motifs regulate CD4 activity

CD4+ T cells use T cell receptor (TCR)–CD3 complexes, and CD4, to respond to peptide antigens within MHCII molecules (pMHCII). We report here that, through ~435 million years of evolution in jawed vertebrates, purifying selection has shaped motifs in the extracellular, transmembrane, and intracellul...

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Bibliographic Details
Main Authors: Mark S Lee, Peter J Tuohy, Caleb Y Kim, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
T cell
CD4
evolution
TCR
signaling
activation
Online Access:https://elifesciences.org/articles/79508

Internet

https://elifesciences.org/articles/79508

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