Sex-specific differences in the mechanisms for enhanced thromboxane A2-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia

Sex-specific differences in the mechanisms for enhanced thromboxane A2-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia

Abstract Background Prenatal hypoxia, a common pregnancy complication, leads to impaired cardiovascular outcomes in the adult offspring. It results in impaired vasodilation in coronary and mesenteric arteries of the adult offspring, due to reduced nitric oxide (NO). Thromboxane A2 (TxA2) is a potent...

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Bibliographic Details
Main Authors: Murilo E. Graton, Floor Spaans, Rose He, Paulami Chatterjee, Raven Kirschenman, Anita Quon, Tom J. Phillips, C. Patrick Case, Sandra T. Davidge
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Biology of Sex Differences
Subjects:
Pregnancy complications
Prenatal hypoxia
Developmental origins of health and disease
Placental treatment
Coronary arteries
Mesenteric arteries
Online Access:https://doi.org/10.1186/s13293-024-00627-x

Internet

https://doi.org/10.1186/s13293-024-00627-x

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