Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Ubiquitination by HECT E3 enzymes regulates myriad processes, including tumor suppression, transcription, protein trafficking, and degradation. HECT E3s use a two-step mechanism to ligate ubiquitin to target proteins. The first step is guided by interactions between the catalytic HECT domain and the...

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Bibliographic Details
Main Authors: Hari B Kamadurai, Yu Qiu, Alan Deng, Joseph S Harrison, Chris MacDonald, Marcelo Actis, Patrick Rodrigues, Darcie J Miller, Judith Souphron, Steven M Lewis, Igor Kurinov, Naoaki Fujii, Michal Hammel, Robert Piper, Brian Kuhlman, Brenda A Schulman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-08-01
Series:eLife
Subjects:
ubiquitin
HECT
E3 ligase
E2 conjugating enzyme
NEDD4
Rsp5
Online Access:https://elifesciences.org/articles/00828

Internet

https://elifesciences.org/articles/00828

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