Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion

Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion

Abstract Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, the transcription factor residing in the PD-L1 super-enhancer has not been comprehensively explored. Through saturated CRISPR-Cas9 screening of the core region of the PD-L...

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Bibliographic Details
Main Authors: Conglin Shi, Liuting Chen, Hui Pi, Henglu Cui, Chenyang Fan, Fangzheng Tan, Xuanhao Qu, Rong Sun, Fengbo Zhao, Yihua Song, Yuanyuan Wu, Miaomiao Chen, Wenkai Ni, Lishuai Qu, Renfang Mao, Yihui Fan
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-023-00500-3

Internet

https://doi.org/10.1038/s41389-023-00500-3

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