Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer

Phosphoinositide Conversion Inactivates R‐RAS and Drives Metastases in Breast Cancer

Abstract Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here it is reported that, in a cohort of more than 2000 pat...

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Bibliographic Details
Main Authors: Huayi Li, Lorenzo Prever, Myriam Y. Hsu, Wen‐Ting Lo, Jean Piero Margaria, Maria Chiara De Santis, Cristina Zanini, Marco Forni, Francesco Novelli, Salvatore Pece, Pier Paolo Di Fiore, Paolo Ettore Porporato, Miriam Martini, Hassane Belabed, Marc Nazare, Volker Haucke, Federico Gulluni, Emilio Hirsch
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Advanced Science
Subjects:
breast cancer
focal adhesions
metastases
migration
PI3KC2α
RASA3
Online Access:https://doi.org/10.1002/advs.202103249

Internet

https://doi.org/10.1002/advs.202103249

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