Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated. Experimental determination of the structure of a potassium channel VSD in the intermediate state has previously proven elusive. Here, w...

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Bibliographic Details
Main Authors: Keenan C Taylor, Po Wei Kang, Panpan Hou, Nien-Du Yang, Georg Kuenze, Jarrod A Smith, Jingyi Shi, Hui Huang, Kelli McFarland White, Dungeng Peng, Alfred L George, Jens Meiler, Robert L McFeeters, Jianmin Cui, Charles R Sanders
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
ion channels
voltage-gating
solution NMR spectroscopy
electrophysiology
Online Access:https://elifesciences.org/articles/53901

Internet

https://elifesciences.org/articles/53901

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