The ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch

The ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch

Myocardial damage caused, for example, by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead...

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Bibliographic Details
Main Authors: Laura Rolland, Jourdano Mancilla Abaroa, Adèle Faucherre, Aurélien Drouard, Chris Jopling
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
TRPC6 channel
heart regeneration
AP1 complex
mechanosensation
calcineurin/NFAT pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1186086/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1186086/full

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