SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa

SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: protocol of a multicenter, parallel-group, open-label, randomized clinical trial in Lesotho, Southern Africa

Abstract Background The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two conse...

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Bibliographic Details
Main Authors: Alain Amstutz, Bienvenu Lengo Nsakala, Fiona Vanobberghen, Josephine Muhairwe, Tracy Renée Glass, Beatrice Achieng, Mamorena Sepeka, Katleho Tlali, Lebohang Sao, Kyaw Thin, Thomas Klimkait, Manuel Battegay, Niklaus Daniel Labhardt
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Infectious Diseases
Subjects:
HIV
Viral suppression
Treatment failure
First-line antiretroviral therapy failure
Switch to second-line antiretroviral therapy
Lesotho
Online Access:http://link.springer.com/article/10.1186/s12879-018-2979-y

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http://link.springer.com/article/10.1186/s12879-018-2979-y

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