A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery

A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery

Towards clinical translation of cancer nanomedicine, it is important to systematically investigate the various parameters related to nanoparticle (NP) physicochemical properties, tumor characteristics, and inter-individual variability that affect the tumor delivery efficiency of therapeutic nanomate...

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Bibliographic Details
Main Authors: Prashant Dogra, Joseph D. Butner, Javier Ruiz Ramírez, Yao-li Chuang, Achraf Noureddine, C. Jeffrey Brinker, Vittorio Cristini, Zhihui Wang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Cancer nanotherapy
Enhanced permeability and retention effect
Mechanistic mathematical modeling
PBPK
Pharmacokinetics
Sensitivity analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019305653

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http://www.sciencedirect.com/science/article/pii/S2001037019305653

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