Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

Alpha-amylase is widely exploited as a drug target for preventing postprandial hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant-derived pregnanes is not fully understood. Herein, we used in vitro, in silico, and in vivo studies to provide further insights in...

Full description

Bibliographic Details
Main Authors: Oludare M. Ogunyemi, Gideon A. Gyebi, Afolabi Saheed, Jesse Paul, Victoria Nwaneri-Chidozie, Olufunke Olorundare, Joseph Adebayo, Mamoru Koketsu, Nada Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Charles O. Olaiya
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
diabetes
alpha-amylase
G. latifolium
phytochemicals
pregnanes
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.866719/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.866719/full

Similar Items