Changing shapes of glycogen-autophagy nexus in neurons: Perspective from a rare epilepsy
In brain, glycogen metabolism is predominantly restricted to astrocytes but it also indirectly supports neuronal functions. Increased accumulation of glycogen in neurons is mysteriously pathogenic triggering neurodegeneration as seen in ‘Lafora disease’ and in other transgenic animal models of neuro...
Main Authors: | Pankaj Kumar Singh, Sweta eSingh |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2015-02-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00014/full |
Similar Items
-
Laforin targets malin to glycogen in Lafora progressive myoclonus epilepsy
by: Sharmistha Mitra, et al.
Published: (2023-01-01) -
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism
by: Or Kakhlon, et al.
Published: (2021-09-01) -
Deleterious effects of neuronal accumulation of glycogen in flies and mice
by: Jordi Duran, et al.
Published: (2012-05-01) -
SGK1 (glucose transport), dishevelled2 (wnt signaling), LC3/p62 (autophagy) and p53 (apoptosis) proteins are unaltered in Lafora disease
by: Peixiang Wang, et al.
Published: (2016-10-01) -
Role of Astrocytes in the Pathophysiology of Lafora Disease and Other Glycogen Storage Disorders
by: Jordi Duran
Published: (2023-02-01)