Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Abstract Background Though immune checkpoint blockade (ICB) against PD-1 has shown success in the treatment of lung cancer, not all patients respond. We have previously shown that adoptive transfer of double negative T (DNT) cells expanded from healthy donors can target leukemia but their role in tr...

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Bibliographic Details
Main Authors: Linan Fang, Dalam Ly, Si-si Wang, Jong Bok Lee, Hyeonjeong Kang, Hao Xu, Junlin Yao, Ming-sound Tsao, Wei Liu, Li Zhang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Double negative T cells
Adoptive cell therapy
Lung cancer
NSCLC
Checkpoint blockade
Anti-PD-1
Online Access:http://link.springer.com/article/10.1186/s13046-019-1126-y

Internet

http://link.springer.com/article/10.1186/s13046-019-1126-y

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