Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L

Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L

Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause 5–10% acute leukemias with poor clinical outcomes. Protein–protein interactions (PPI) between the most frequent MLL fusion partner proteins AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rea...

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Bibliographic Details
Main Authors: Xin Li, Xiaowei Wu, Shenyou Nie, Jidong Zhao, Yuan Yao, Fangrui Wu, Chandra Bhushan Mishra, Md Ashraf-Uz-Zaman, Bala Krishna Moku, Yongcheng Song
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
MLL-rearranged leukemia
super elongation complexes
small-molecule inhibitor
protein–protein interaction
cancer therapeutics
Online Access:https://www.mdpi.com/2072-6694/15/21/5283

Internet

https://www.mdpi.com/2072-6694/15/21/5283

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