Adipose-derived stem cells prevent the onset of bisphosphonate-related osteonecrosis of the jaw through transforming growth factor β-1-mediated gingival wound healing

Adipose-derived stem cells prevent the onset of bisphosphonate-related osteonecrosis of the jaw through transforming growth factor β-1-mediated gingival wound healing

Abstract Background Due to its complex pathogenesis and low clinical cure rate, bisphosphonate-related osteonecrosis of the jaw (BRONJ) poses a substantial challenge for oral and maxillofacial surgeons. Therefore, the treatment of BRONJ should focus on prevention. In clinical studies, primary wound...

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Bibliographic Details
Main Authors: Xiaolong Zang, Linhai He, Lu Zhao, Yang He, E. Xiao, Yi Zhang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Stem Cell Research & Therapy
Subjects:
Bisphosphonate-related osteonecrosis of the jaw
Wound healing
Zoledronic acid
Fibroblast
Fibronectin
Adipose-derived mesenchymal stem cells
Online Access:http://link.springer.com/article/10.1186/s13287-019-1277-y

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http://link.springer.com/article/10.1186/s13287-019-1277-y

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