Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression

Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression

Prostate cancer (PCa) progression is characterized by the emergence of resistance to androgen deprivation therapy (ADT). AKT/PKB has been directly implicated in PCa progression, often due to the loss of PTEN and activation of PI3K>PDK1>AKT signaling. However, the regulatory network of AKT rema...

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Bibliographic Details
Main Authors: Md Imtiaz Khalil, Christopher Madere, Ishita Ghosh, Rosalyn M. Adam, Arrigo De Benedetti
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pathophysiology
Subjects:
TLK1
AKTIP/FT1/FTS
PKB/AKT
prostate cancer
castration-resistant prostate cancer
apoptosis
Online Access:https://www.mdpi.com/1873-149X/28/3/23

Internet

https://www.mdpi.com/1873-149X/28/3/23

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