Incorporation of apolipoprotein E into HBV–HCV subviral envelope particles to improve the hepatitis vaccine strategy

Abstract Hepatitis C is a major threat to public health for which an effective treatment is available, but a prophylactic vaccine is still needed to control this disease. We designed a vaccine based on chimeric HBV–HCV envelope proteins forming subviral particles (SVPs) that induce neutralizing anti...

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Bibliographic Details
Main Authors: Elsa Gomez-Escobar, Julien Burlaud-Gaillard, Clara Visdeloup, Adeline Ribeiro E. Silva, Pauline Coutant, Philippe Roingeard, Elodie Beaumont
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01428-7