Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Mycobacterium tuberculosis (Mtb) employs multiple strategies to evade host immune responses and persist within macrophages. We have previously shown that the cell envelope-associated Mtb serine hydrolase, Hip1, prevents robust macrophage activation and dampens host pro-inflammatory responses, allowi...

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Bibliographic Details
Main Authors: Jacqueline L Naffin-Olivos, Maria Georgieva, Nathan Goldfarb, Ranjna Madan-Lala, Lauren Dong, Erica Bizzell, Ethan Valinetz, Gabriel S Brandt, Sarah Yu, Daniil E Shabashvili, Dagmar Ringe, Ben M Dunn, Gregory A Petsko, Jyothi Rengarajan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4022732?pdf=render

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http://europepmc.org/articles/PMC4022732?pdf=render

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