Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.

Birt-Hogg-Dube (BHD) is a tumor suppressor gene syndrome associated with fibrofolliculomas, cystic lung disease, and chromophobe renal cell carcinoma. In seeking to elucidate the pathogenesis of BHD, we discovered a physical interaction between folliculin (FLCN), the protein product of the BHD gene,...

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Bibliographic Details
Main Authors: Doug A Medvetz, Damir Khabibullin, Venkatesh Hariharan, Pat P Ongusaha, Elena A Goncharova, Tanja Schlechter, Thomas N Darling, Ilse Hofmann, Vera P Krymskaya, James K Liao, Hayden Huang, Elizabeth P Henske
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3490959?pdf=render

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http://europepmc.org/articles/PMC3490959?pdf=render

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