27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor

Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol: 1) oxygen addition at the double bond to giv...

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Bibliographic Details
Main Authors: Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Lipid Research
Subjects:
CYP27A1
oxysterols
5,6-epoxycholestanol
cholestane-3β,5α,6β-triol
oncosterone
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001529

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http://www.sciencedirect.com/science/article/pii/S0022227523001529

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