27-Hydroxylation of oncosterone by CYP27A1 switches its activity from pro-tumor to anti-tumor
Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from cholesterol: 1) oxygen addition at the double bond to giv...
Main Authors: | Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227523001529 |
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