Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer

Abstract Background Combination chemotherapy has contributed to increased survival from Hodgkin disease (HD) and testicular cancer (TC). However, questions concerning the quality of spermatozoa after treatment have arisen. While studies have shown evidence of DNA damage and aneuploidy in spermatozoa...

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Bibliographic Details
Main Authors: Donovan Chan, Kathleen Oros Klein, Antoni Riera-Escamilla, Csilla Krausz, Cristian O’Flaherty, Peter Chan, Bernard Robaire, Jacquetta M. Trasler
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Clinical Epigenetics
Subjects:
Sperm
DNA methylation
Chemotherapy
Testicular cancer
Hodgkin disease
Online Access:https://doi.org/10.1186/s13148-022-01417-1

Internet

https://doi.org/10.1186/s13148-022-01417-1

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