An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study

Cytochrome P450 2D6 (<i>CYP2D6</i>) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for <i>CYP2D6</i> phenotyping. The objective of the CY...

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Bibliographic Details
Main Authors: Blandine De La Gastine, Soizic Percevault, Laurent Varin, Nicolas Richard, Fabienne Fobe, Benoît Plaud, Georges Daccache, Vincent Compere, Jean-Jacques Parienti, Antoine Coquerel, Magalie Loilier, Nathalie Bleyzac, Laurent Bourguignon, Sylvain Goutelle, Véronique Lelong-Boulouard
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
tramadol
<i>CYP2D6</i>
pharmacogenetics
pharmacogenomics
Online Access:https://www.mdpi.com/1999-4923/14/10/2177

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https://www.mdpi.com/1999-4923/14/10/2177

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