Killer Archaea: Virus-Mediated Antagonism to CRISPR-Immune Populations Results in Emergent Virus-Host Mutualism

Killer Archaea: Virus-Mediated Antagonism to CRISPR-Immune Populations Results in Emergent Virus-Host Mutualism

ABSTRACT Theory, simulation, and experimental evolution demonstrate that diversified CRISPR-Cas immunity to lytic viruses can lead to stochastic virus extinction due to a limited number of susceptible hosts available to each potential new protospacer escape mutation. Under such conditions, theory pr...

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Bibliographic Details
Main Authors: Samantha J. DeWerff, Maria A. Bautista, Matthew Pauly, Changyi Zhang, Rachel J. Whitaker
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
archaea
CRISPR-Cas
chronic viruses
coevolution
mutualism
symbiosis
Online Access:https://journals.asm.org/doi/10.1128/mBio.00404-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00404-20

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