Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression

Pyruvate Dehydrogenase Kinase 1 inhibition mediated oxidative phosphorylation enhancement in cartilage promotes osteoarthritis progression

Abstract Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing evidence showed that glucose metabolism impacts joint homeostasis and an imbalance between glycolysis and oxidative phosphorylation (OXPHOS) may exacerbate OA progression, however, a definitive link is y...

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Bibliographic Details
Main Authors: Xian Yang, Qingsong Jiang, Tiankuo Luan, Chao Yu, Zhibo Liu, Ting Wang, Jingyuan Wan, Jiayu Huang, Ke Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
PDK1
ECM
Glucose metabolism
Inflammation
Online Access:https://doi.org/10.1186/s12891-023-06585-6

Internet

https://doi.org/10.1186/s12891-023-06585-6

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