Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer

Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer

Converting an immunosuppressive melanoma microenvironment into one that favors the induction of antitumor immunity is indispensable for effective cancer immunotherapy. In the current study we demonstrate that oat-derived β-(1-3)-(1-4)-glucan of 200 kDa molecular size (BG34-200) previously shown to m...

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Bibliographic Details
Main Authors: Mei Zhang, Liane Chun, Victor Sandoval, Hallie Graor, Jay Myers, Joseph Nthale, Peter Rauhe, Zachary Senders, Kevin Choong, Alex Y. Huang, Julian Kim
Format: Article
Language:English
Published: Taylor & Francis Group 2018-02-01
Series:OncoImmunology
Subjects:
antitumor immunity
immune modulator
macrophage
melanoma
oat β-glucan
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1387347

Internet

http://dx.doi.org/10.1080/2162402X.2017.1387347

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