Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer

Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer

Converting an immunosuppressive melanoma microenvironment into one that favors the induction of antitumor immunity is indispensable for effective cancer immunotherapy. In the current study we demonstrate that oat-derived β-(1-3)-(1-4)-glucan of 200 kDa molecular size (BG34-200) previously shown to m...

Full description

Bibliographic Details
Main Authors:	Mei Zhang, Liane Chun, Victor Sandoval, Hallie Graor, Jay Myers, Joseph Nthale, Peter Rauhe, Zachary Senders, Kevin Choong, Alex Y. Huang, Julian Kim
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-02-01
Series:	OncoImmunology
Subjects:	antitumor immunity immune modulator macrophage melanoma oat β-glucan
Online Access:	http://dx.doi.org/10.1080/2162402X.2017.1387347

Similar Items

β-Glucan in invertebrates
by: V Vetvicka, et al.
Published: (2004-11-01)

b-Glucan in invertebrates
by: V Vetvicka, et al.
Published: (2004-11-01)

Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles
by: Mei Zhang, et al.
Published: (2018-02-01)

The impact of oat structure and β-glucan on in vitro lipid digestion
by: Myriam M.L. Grundy, et al.
Published: (2017-11-01)

β-Glucan and parasites
by: Vetvicka V., et al.
Published: (2018-09-01)

Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling
by: Bo Liu, et al.
Published: (2018-02-01)

Development of innovative health beneficial bread using a fermented fibre-glucan product
by: Lenka BLAŽEKOVÁ, et al.
Published: (2015-04-01)

Beneficial Effects of Oat Beta-Glucan Dietary Supplementation in Colitis Depend on Its Molecular Weight
by: Ewa Żyła, et al.
Published: (2019-10-01)

Engineered Probiotic‐Based Personalized Cancer Vaccine Potentiates Antitumor Immunity through Initiating Trained Immunity
by: Zhaoxia Chen, et al.
Published: (2024-01-01)

Bioactive oat β-glucan reduces LDL cholesterol in Caucasians and non-Caucasians
by: Wolever Thomas MS, et al.
Published: (2011-11-01)

The impact of storage on the sensory, viscosity and chemical characteristics of yogurt fortified with oat β-glucan
by: Xiaoqing Qu
Published: (2021-09-01)

High β-Glucans Oats for Healthy Wheat Breads: Physicochemical Properties of Dough and Breads
by: Valentina Astiz, et al.
Published: (2022-12-01)

ULTRASOUND-ASSISTED AND ENZYMATIC-BASED METHOD FOR ISOLATION OF β-GLUCANS FROM OAT BRAN
by: V. V. Korsa, et al.
Published: (2023-02-01)

Antioxidant activity, β-glucan and lipid contents of oat varieties
by: Lucia Brindzová, et al.
Published: (2008-06-01)

Effect of Oat β-Glucan on the Rheological Characteristics and Microstructure of Set-Type Yogurt
by: Xiaoqing Qu, et al.
Published: (2021-08-01)

Effects of β-Glucan Glycosylation on Functional Properties and Antioxidant Activity of Naked Oat Protein
by: Zhiwei YANG, et al.
Published: (2022-11-01)

Three Different Types of β-Glucans Enhance Cognition: The Role of the Gut-Brain Axis
by: Minmin Hu, et al.
Published: (2022-03-01)

Development of Fish Immunity and the Role of β-Glucan in Immune Responses
by: Marianna V. Rodrigues, et al.
Published: (2020-11-01)

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression
by: Vaclav Vetvicka, et al.
Published: (2021-03-01)

β-glucans and their significance for the preparation of functional foods - a review
by: Michaela Havrlentová, et al.
Published: (2011-02-01)

Effects of Oat Beta-Glucan Intake on Lipid Profiles in Hypercholesterolemic Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by: Junhui Yu, et al.
Published: (2022-05-01)

Impact of purified oat 1-3,1-4-β-d-glucan of different molecular weight on alleviation of inflammation parameters during gastritis
by: D. Suchecka, et al.
Published: (2017-01-01)

IMMUNOMODULATING PROPERTIES OF THE PLANT GLUCANS AT EXPERIMENTAL IMMUNODEPRESSION
by: V. B. Khobrakova, et al.
Published: (2012-11-01)

Immunomodulatory Effect and Biological Significance of β-Glucans
by: Xuemei Zhong, et al.
Published: (2023-05-01)

Oat and Barley in the Food Supply and Use of Beta Glucan Health Claims
by: Jaimee Hughes, et al.
Published: (2021-07-01)

Physicochemical and Digestive Properties of Yam Starch/Oat β-Glucan Blends
by: Jingqi ZHOU, et al.
Published: (2022-09-01)

β-Glucan as Trained Immunity-Based Adjuvants for Rabies Vaccines in Dogs
by: Simon Paris, et al.
Published: (2020-10-01)

Synergistic effects of oat β-glucan combined with ultrasound treatment on gel properties of silver carp surimi
by: Xueli He, et al.
Published: (2023-05-01)

Oat β Glucan Ameliorates Renal Function and Gut Microbiota in Diabetic Rats
by: Ruoyu Wang, et al.
Published: (2022-05-01)

Study of Dynamic Accumulation in β-D-Glucan in Oat (<i>Avena sativa</i> L.) during Plant Development
by: Peter Hozlár, et al.
Published: (2022-06-01)

Anti-Inflammatory Activity of Oat Beta-Glucans in a Crohn’s Disease Model: Time- and Molar Mass-Dependent Effects
by: Ewa Żyła, et al.
Published: (2021-04-01)

Immune-enhancing effect of water-soluble beta-glucan derived from enzymatic hydrolysis of yeast glucan
by: Yingji Xin, et al.
Published: (2022-07-01)

Targeting β-glucans, vital components of the Pneumocystis cell wall
by: Mengyan Wang, et al.
Published: (2023-02-01)

Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials
by: Vaclav Vetvicka, et al.
Published: (2019-03-01)

BG34-200 Immunotherapy of Advanced Melanoma
by: Veronique Roche, et al.
Published: (2022-11-01)

Effect of Oat Fiber Preparations with Different Contents of β-Glucan on the Formation of Acrylamide in Dietary Bread (Rusks)
by: Karolina Miśkiewicz, et al.
Published: (2024-01-01)

<i>Euglena gracilis</i> β-Glucans (1,3): Enriching Colostrum of Sow for Enhanced Piglet Immunity
by: Rafael Humberto de Carvalho, et al.
Published: (2023-11-01)

Effects of Oat β-Glucan on the Textural and Sensory Properties of Low-Fat Set Type Pea Protein Yogurt
by: Peiyao Zhao, et al.
Published: (2023-03-01)

β-glucans from Agaricus bisporus mushroom products drive Trained Immunity
by: Sarah Case, et al.
Published: (2024-02-01)

Shaping the Innate Immune Response by Dietary Glucans: Any Role in the Control of Cancer?
by: Manuela Del Cornò, et al.
Published: (2020-01-01)