The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins

The Role of Structure and Biophysical Properties in the Pleiotropic Effects of Statins

Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGR), but statin intolerance from pleiotropic effects have been...

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Bibliographic Details
Main Authors: Christopher Murphy, Evelyne Deplazes, Charles G. Cranfield, Alvaro Garcia
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
statins
membranes
pleiotropic effects
hepatoselectivity
drug-membrane interactions
Online Access:https://www.mdpi.com/1422-0067/21/22/8745

Internet

https://www.mdpi.com/1422-0067/21/22/8745

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