The role of the different CD3γ domains in TCR expression and signaling

The role of the different CD3γ domains in TCR expression and signaling

The CD3 subunits of the T-cell antigen receptor (TCR) play a central role in regulation of surface TCR expression levels. Humans who lack CD3γ (γ—) show reduced surface TCR expression levels and abolished phorbol ester (PMA)-induced TCR down-regulation. The response to PMA is mediated by a double le...

Full description

Bibliographic Details
Main Authors: Beatriz Garcillán, Rebeca F. Megino, Marta Herrero-Alonso, Alberto C. Guardo, Veronica Perez-Flores, Claudia Juraske, Vincent Idstein, Jose M. Martin-Fernandez, Carsten Geisler, Wolfgang W. A. Schamel, Ana V. Marin, Jose R. Regueiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
CD3 chimeras
T cell receptor
CD3δ
CD3γ
domains
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.978658/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.978658/full

Similar Items