Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs.

Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs.

Multispecific proteins play a major role in controlling various functions such as signaling, regulation of transcription/translation, and immune response. Hence, a thorough understanding of the atomic-level principles governing multispecific interactions is important not only for the advancement of...

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Bibliographic Details
Main Authors: Oz Sharabi, Jason Shirian, Moran Grossman, Mario Lebendiker, Irit Sagi, Julia Shifman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3977929?pdf=render

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http://europepmc.org/articles/PMC3977929?pdf=render

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