IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

IRF1 Is Required for MDA5 (IFIH1) Induction by IFN-α, LPS, and poly(I:C) in Murine Macrophages

Melanoma differentiation-associated protein 5 (MDA5) induces type I interferons (IFNs) after the recognition of viral RNA. In addition, gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene, which encodes MDA5, lead to type I interferonopathies. Here, we show tha...

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Bibliographic Details
Main Authors: Iris Aparici-Herraiz, Guillem Sánchez-Sánchez, Carlos Batlle, Pere Rehues, Martí López-Serrat, Lorena Valverde-Estrella, Jorge Lloberas, Antonio Celada
Format: Article
Language:English
Published: Karger Publishers 2022-11-01
Series:Journal of Innate Immunity
Subjects:
macrophages
interferons
gene regulation
inflammation
reactive oxygen species
Online Access:https://www.karger.com/Article/FullText/527008

Internet

https://www.karger.com/Article/FullText/527008

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