Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.

Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7.

Paraplegin is an m-AAA protease of the mitochondrial inner membrane that is linked to hereditary spastic paraplegias. The gene encodes an FtsH-homology protease domain in tandem with an AAA+ homology ATPase domain. The protein is believed to form a hexamer that uses ATPase-driven conformational chan...

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Bibliographic Details
Main Authors: Tobias Karlberg, Susanne van den Berg, Martin Hammarström, Johanna Sagemark, Ida Johansson, Lovisa Holmberg-Schiavone, Herwig Schüler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2734466?pdf=render

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http://europepmc.org/articles/PMC2734466?pdf=render

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