Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies

Repolarization of Tumor-Infiltrating Myeloid Cells for Augmentation of CAR T Cell Therapies

Although CAR T cell therapies have proven to be effective in treating hematopoietic cancers, their abilities to regress solid tumors have been less encouraging. Mechanisms to explain these disparities have focused primarily on differences in cancer cell heterogeneity, barriers to CAR T cell penetrat...

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Bibliographic Details
Main Authors: Weichuan Luo, John V. Napoleon, Fenghua Zhang, Yong Gu Lee, Bingbing Wang, Karson S. Putt, Philip S. Low
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
CAR T cells
combinational immunotherapy
TLR7 agonist
tumor associated macrophage (TAM)
reprograming tumor microenvironment
myeloid-derived suppressor cell (MDSC)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.816761/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.816761/full

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