New use for old drug: Local delivery of puerarin facilitates critical-size defect repair in rats by promoting angiogenesis and osteogenesis

New use for old drug: Local delivery of puerarin facilitates critical-size defect repair in rats by promoting angiogenesis and osteogenesis

Objectives: Large bone defect repair is a challenging clinical problem due to limited self-repair ability. A well-designed bone filling product should possess the ability to induce tissue in-growth and facilitate neovascularization and new bone formation. Puerarin has been used in clinics for a long...

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Bibliographic Details
Main Authors: Huijuan Cao, Lingli Li, Ling Li, Xiangbo Meng, Yanzhi Liu, Wenxiang Cheng, Peng Zhang, Yongbo Gao, Ling Qin, Xinluan Wang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Puerarin
PLGA/TCP
Angiogenesis
Osteogenesis
Drug/device combination implant
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22000407

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http://www.sciencedirect.com/science/article/pii/S2214031X22000407

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