BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine

Diabetic kidney disease is one of the most serious microvascular complications of diabetes. It progresses irreversibly to end-stage renal disease if left untreated. Bone morphogenetic protein (BMP)-7 is a negative regulator of organ fibrosis and may also play an essential role in tubulointerstitial...

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Bibliographic Details
Main Authors: Yawen Xiao, Dan Liang, Zhiyang Li, Zhaowei Feng, Zhiping Yuan, Fan Zhang, Yuanyuan Wang, Yuxia Zhou, Mingjun Shi, Lingling Liu, Ying Xiao, Bing Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
BMP-7
Id2
MAPKs
oxymatrine
tubulointerstitial fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.900346/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.900346/full

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