Super-enhancers complexes zoom in transcription in cancer

Super-enhancers complexes zoom in transcription in cancer

Abstract Super-enhancers (SEs) consist of multiple typical enhancers enriched at high density with transcription factors, histone-modifying enzymes and cofactors. Oncogenic SEs promote tumorigenesis and malignancy by altering protein-coding gene expression and noncoding regulatory element function....

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Bibliographic Details
Main Authors: MengTing Wang, QingYang Chen, ShuJie Wang, Han Xie, Jun Liu, RuiXiang Huang, YuFei Xiang, YanYi Jiang, DaSheng Tian, ErBao Bian
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Super-enhancer
Transcription factors
Histone-modifying enzymes
Cofactors
Noncoding RNA
Online Access:https://doi.org/10.1186/s13046-023-02763-5

Internet

https://doi.org/10.1186/s13046-023-02763-5

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