Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands

Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides, and Their Effect on the 5α-Reductase Isoform 2, the Androgen Receptor, and Androgen-Dependent Glands

Background: Benign Prostatic Hyperplasia (BPH), and Prostate Cancer (PCa) are androgen-dependent diseases. PPCa is associated with excessive signalling of the androgen receptor (AR) due to the binding of 5α-dihydrotestosterone (5α-DHT) and testosterone (T). BPH is related to high levels of 5α-DHT, b...

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Bibliographic Details
Main Authors: Juan C. Lopez-Lezama, Marisa Cabeza, Yvonne Heuze, Araceli Sánchez, José L. Rojas, Norma A. Valencia-Islas
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2022-07-01
Series:Pharmaceutical Sciences
Subjects:
androstane analogues
androgen-dependent afflictions
prostate gland
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-28-433.pdf

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https://ps.tbzmed.ac.ir/PDF/ps-28-433.pdf

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