Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice

Local immune checkpoint blockade therapy by an adenovirus encoding a novel PD-L1 inhibitory peptide inhibits the growth of colon carcinoma in immunocompetent mice

A novel peptide that interferes with the PD-1/PD-L1 immune checkpoint pathway, termed PD-L1 inhibitory peptide 3 (PD-L1ip3), was computationally designed, experimentally validated for its specific binding to PD-L1, and evaluated for its antitumor effects in cell culture and in a mouse colon carcinom...

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Bibliographic Details
Main Authors: Susumu Ishiguro, Deepa Upreti, Molly Bassette, E.R. Azhagiya Singam, Ravindra Thakkar, Mayme Loyd, Makoto Inui, Jeffrey Comer, Masaaki Tamura
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Translational Oncology
Subjects:
PD-L1 inhibitory peptide secretory gene
PD-L1 inhibitory peptide
Adenovirus
Colon cancer
PD-L1 blockade therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321003284

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http://www.sciencedirect.com/science/article/pii/S1936523321003284

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