Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2

Multiple endocrine neoplasia type 2 is an inherited cancer syndrome characterized by tumors of thyroid and adrenal tissues. Germline mutations of the REarranged during Transfection (RET) proto-oncogene, leading to its unregulated activation, are the underlying cause of this disease. Multiple endocri...

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Bibliographic Details
Main Authors: Simona M. Wagner, ShuJun Zhu, Adrian C. Nicolescu, Lois M. Mulligan
Format: Article
Language:English
Published: Elsevier España 2012-01-01
Series:Clinics
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012001300014