Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium

Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium

BackgroundDeveloping effective approaches for postoperative delirium has been hampered due to the lack of a pathophysiologically similar animal model to offer insights into the pathogenesis. The study, therefore, aimed to develop a delirium-like mouse model and explore the underlying mechanism.Metho...

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Bibliographic Details
Main Authors: Jing-Lan Mu, Xiao-Dong Liu, Ye-Hong Dong, Ying-Ying Fang, Shi-Da Qiu, Fu Zhang, Ke-Xuan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Medicine
Subjects:
delirium
repeated intestinal I/R
IL-6
microglia
BLA
QUIN
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.998397/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.998397/full

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